Caps Lock
Colemak keeps many QWERTY keys in place, including Z X C V and most punctuation, but moves the most frequent letters to the home row: A R S T for the left hand and N E I O for the right.
Practise with type by position so you do not have to change your system layout, follow the lessons and take short daily tests. Shortcuts like Ctrl+C and Ctrl+V stay where they were.